Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 11/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448130 | 0.75 | RHEB (0.52) | DYRK1AKDM4E | |
| SCHEMBL8200409 | 0.70 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTAR | |
| SCHEMBL1429301 | 0.70 | ERN1 (0.34) | DYRK1AKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL5667763 | 0.69 | DYRK1A (0.37) | DYRK1AKDM4EALDH1A1MAPTAR | |
| SCHEMBL6292067 | 0.69 | MEN1 (0.46) | DYRK1AKDM4EALDH1A1MAPTAR | |
| SCHEMBL1772236 | 0.69 | KDM4E (0.65) | KDM4EALDH1A1AR | |
| SCHEMBL29957902 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1MAPTARCYP1A2 | |
| SCHEMBL29956508 | 0.67 | CA2 (0.54) | KDM4EALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL5828348 | 0.67 | CA2 (0.54) | KDM4EALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL27566870 | 0.66 | KMT2A (0.44) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071522-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS METHIONYL T-RNA SYNTHETASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |