SCHEMBL8215216

SCHEMBL8215216

C=C(O[Si](C)(C)C)c1ccc(OC)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.48
CES2 O00748 2/20 0.47
CES1 P23141 2/20 0.47
CA1 P00915 6/20 0.45
CA2 P00918 6/20 0.45
CA12 O43570 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
NR1I2 O75469 1/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
PARP1 P09874 1/20 0.44
PARP10 Q53GL7 1/20 0.44
PARP2 Q9UGN5 1/20 0.44
PARP4 Q9UKK3 1/20 0.44
KDM4E B2RXH2 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8954661 0.84 MAPT (0.32) MAPTNR1I2
SCHEMBL28971992 0.82 MAPT (0.32) MAPT
SCHEMBL17210427 0.79 NR1I2 (0.48) MAPTCES2CES1CA1CA2
SCHEMBL19938127 0.79 ALDH1A1 (0.39) MAPTCES2CES1CA2ALDH1A1
SCHEMBL10872940 0.79 CA1 (0.56) MAPTCES2CES1CA1CA2
SCHEMBL756485 0.79 NR1I2 (0.56) MAPTCES2CES1CA1CA2
SCHEMBL29177284 0.78 CES2 (0.38) MAPTCES2CES1CA1CA2
SCHEMBL7338642 0.78 CES2 (0.38) MAPTCES2CES1CA1CA2
SCHEMBL7237319 0.78 CES2 (0.38) CES2CES1CA1CA2ALDH1A1
SCHEMBL21848427 0.77 CA1 (0.52) MAPTCA1CA2CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676920-A1 PHOTOLABILE CYCLIC ACETALS AND KETALS FOR THE LIGHT-INDUCED DELIVERY OF ACTIVE ALDEHYDES AND KETONES Firmenich SA (CH) 2026-01-14 EP disclosed
WO-2024218086-A1 PHOTOLABILE CYCLIC ACETALS AND KETALS FOR THE LIGHT-INDUCED DELIVERY OF ACTIVE ALDEHYDES AND KETONES FIRMENICH SA (CH) 2024-10-24 WO disclosed
CN-114213254-B Beta-nitroketone and preparation method and application method thereof 北京师范大学 2023-04-25 CN disclosed
CN-114213254-A Beta-nitroketone, and preparation method and application method thereof 北京师范大学 2022-03-22 CN disclosed
US-20130059924-A1 PHOTOSTABILISERS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2013-03-07 US disclosed
EP-0770577-B1 Fullerene derivatives as free-radical scavengers CHIANG LONG Y (TW) 2000-03-29 EP disclosed
US-5648523-A Fullerene derivatives as free-radical scavengers NATIONAL SCIENCE COUNCIL (TW) 1997-07-15 US disclosed
EP-0770577-A1 Fullerene derivatives as free-radical scavengers Chiang, Long Y. (TW) 1997-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130059924-A1 PHOTOSTABILISERS ALDH1A1, ALDH18A1, ALDH1A2 MAPT 362/4885CES2 610/4885CES1 446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.