SCHEMBL8215809

SCHEMBL8215809

CCCC1CCC(CCc2ccc(-c3ccc(CCC4CCC(COC)CC4)c(F)c3)cc2)CC1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.34
RARA P10276 1/20 0.34
RARG P13631 1/20 0.34
HTR2A P28223 3/20 0.34
HTR2C P28335 3/20 0.34
GPR84 Q9NQS5 1/20 0.34
MAOB P27338 2/20 0.33
MAOA P21397 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8219129 1.00 RARB (0.34) RARBRARARARGHTR2AHTR2C
SCHEMBL8216899 0.92 RARB (0.40) RARBRARARARGHTR2AHTR2C
SCHEMBL8218507 0.89 CYP2C9 (0.40) HTR2AHTR2C
SCHEMBL7030005 0.88 GPR84 (0.38) RARBRARARARGGPR84MAOB
SCHEMBL8219141 0.86 OPRL1 (0.38) RARBRARARARGGPR84
SCHEMBL8220224 0.86 FFAR4 (0.35) RARBGPR84MAOB
SCHEMBL8216127 0.86 OPRL1 (0.38) RARBRARARARGGPR84
SCHEMBL8219356 0.86 FFAR4 (0.35) RARBGPR84MAOB
SCHEMBL7030006 0.84 RARB (0.39) RARBRARARARGHTR2AHTR2C
SCHEMBL8209357 0.83 GPR84 (0.38) GPR84MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117361-A FOUR RING COMPOUND HAVING AN ALKYL GROUP SUBSTITUTED WITH ONE OR MORE ETHERS, AND A HALOGEN ATOM SUBSTITUTED BENZENE RING; BROAD TEMPERATURE RANGE OF NEMATIC PHASE, HIGHER MISCIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS, AND CHEMICAL STABILITY CHISSO CORP. (JP) 2000-09-12 US disclosed
EP-0891961-A1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED 1,4-PHENYLENE SKELETONS, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORPORATION (JP) 1999-01-20 EP disclosed