Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.62 |
| ▸ | PDE2A | O00408 | 3/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | PNP | P00491 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 3/20 | 0.48 |
| ▸ | CD99 | P14209 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215939 | 1.00 | ADORA3 (0.62) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL3740994 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL7768864 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL14518668 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL3746582 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL3740999 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL5361537 | 0.90 | ADORA3 (0.63) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL8216884 | 0.88 | AHCY (0.58) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL8215986 | 0.88 | AHCY (0.55) | ADORA3ADORA2AADORA1PDE2APDE4D | |
| SCHEMBL8216887 | 0.88 | AHCY (0.58) | ADORA3ADORA2AADORA1PDE2APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103707-A | TREATMENT OF HERPES SIMPLEX VIRUS 1 (HSV-1), HERPES SIMPLEX VIRUS 2 (HSV-2), HUMAN CYTOMEGALOVIRUS (HCMV) AND VARICELLA-ZOSTER VIRUS | YAMASA CORPORATION (JP) | 2000-08-15 | — | — | US | claimed |
| EP-0839813-A1 | 9-(2-DEOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL)PURINE DERIVATIVES | YAMASA CORPORATION (JP) | 1998-05-06 | — | — | EP | claimed |
| EP-3279207-B1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2024-01-24 | — | — | EP | disclosed |
| US-20200262860-A1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2020-08-20 | — | — | US | disclosed |
| US-10662214-B2 | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-05-26 | — | — | US | disclosed |
| US-20180079770-A1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2018-03-22 | — | — | US | disclosed |
| EP-3279207-A1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2018-02-07 | — | — | EP | disclosed |
| US-6103707-A | TREATMENT OF HERPES SIMPLEX VIRUS 1 (HSV-1), HERPES SIMPLEX VIRUS 2 (HSV-2), HUMAN CYTOMEGALOVIRUS (HCMV) AND VARICELLA-ZOSTER VIRUS | YAMASA CORPORATION (JP) | 2000-08-15 | — | — | US | disclosed |
| EP-0839813-A1 | 9-(2-DEOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL)PURINE DERIVATIVES | YAMASA CORPORATION (JP) | 1998-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662214-B2 | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof | TYMP, WEE1, NTPCR | ADORA3 1448/4885ADORA2A 1791/4885ADORA1 632/4885 |
| US-20180079770-A1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | WEE1, WEE2, THEM6 | ADORA3 2076/4885ADORA2A 2445/4885ADORA1 950/4885 |
| US-20200262860-A1 | NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | GOT1, SLC39A11, TYMP | ADORA3 2107/4885ADORA2A 3702/4885ADORA1 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.