Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217541 | 0.83 | PIK3CA (0.51) | PIK3CDPIK3CAMTORNAMPTCYP2C9 | |
| SCHEMBL11926095 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CAMTORNAMPTMAPK1 | |
| SCHEMBL8214218 | 0.83 | PIK3CA (0.66) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8214319 | 0.82 | NAMPT (0.56) | NAMPTCYP2C9 | |
| SCHEMBL8217546 | 0.82 | L3MBTL1 (0.55) | PIK3CDPIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8217442 | 0.81 | PIK3CA (0.51) | PIK3CDPIK3CAMTORMAPK1RAB9A | |
| SCHEMBL8206121 | 0.81 | PIK3CA (0.62) | PIK3CDPIK3CAMTORNAMPTRAB9A | |
| SCHEMBL8215121 | 0.81 | PIK3CA (0.56) | PIK3CDPIK3CAMTORRAB9A | |
| SCHEMBL3601767 | 0.81 | PIK3CA (0.78) | PIK3CDPIK3CAMTOR | |
| SCHEMBL11926829 | 0.80 | PIK3CA (0.52) | PIK3CDPIK3CAMTORNAMPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |