Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926095 | 0.85 | PIK3CD (0.53) | PIK3CAPIK3CDMTORNAMPT | |
| SCHEMBL8217546 | 0.84 | L3MBTL1 (0.55) | PIK3CAPIK3CDL3MBTL1GLATSHR | |
| SCHEMBL8216397 | 0.83 | PIK3CD (0.51) | PIK3CAPIK3CDMTORNAMPTCYP2C9 | |
| SCHEMBL8214218 | 0.83 | PIK3CA (0.66) | PIK3CAPIK3CDMTOR | |
| SCHEMBL11926829 | 0.82 | PIK3CA (0.52) | PIK3CAPIK3CDMTORNAMPTTSHR | |
| SCHEMBL8218782 | 0.82 | PIK3CA (0.54) | PIK3CAPIK3CDMTORHPGD | |
| SCHEMBL8217442 | 0.81 | PIK3CA (0.51) | PIK3CAPIK3CDMTORHPGDTSHR | |
| SCHEMBL8206121 | 0.81 | PIK3CA (0.62) | PIK3CAPIK3CDMTORNAMPTL3MBTL1 | |
| SCHEMBL8215121 | 0.81 | PIK3CA (0.56) | PIK3CAPIK3CDMTORCYP1A2 | |
| SCHEMBL3588757 | 0.81 | PIK3CA (0.78) | PIK3CAPIK3CDMTORCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |