Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205071 | 0.85 | PIK3CA (0.54) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL11925576 | 0.84 | NPC1 (0.51) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL8217541 | 0.84 | PIK3CA (0.51) | L3MBTL1TSHRGLAPIK3CDPIK3CA | |
| SCHEMBL8214218 | 0.84 | PIK3CA (0.66) | PIK3CDPIK3CAKDR | |
| SCHEMBL8214319 | 0.83 | NAMPT (0.56) | KMT2AMEN1 | |
| SCHEMBL8217442 | 0.82 | PIK3CA (0.51) | RAB9AKMT2ASMN1; SMN2ALOX15TSHR | |
| SCHEMBL8216397 | 0.82 | PIK3CD (0.51) | NPC1RAB9ASMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL11926095 | 0.82 | PIK3CD (0.53) | KMT2AMAPTPIK3CDPIK3CAMEN1 | |
| SCHEMBL8215121 | 0.82 | PIK3CA (0.56) | RAB9AKMT2AMAPTPIK3CDPIK3CA | |
| SCHEMBL8206121 | 0.82 | PIK3CA (0.62) | L3MBTL1RAB9AKMT2AMAPTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |