Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577196 | 0.84 | CYP1A2 (0.42) | SMN1; SMN2MMP8ALDH1A1MEN1KMT2A | |
| SCHEMBL12493852 | 0.79 | KMT2A (0.48) | SMN1; SMN2MMP8ALDH1A1MEN1KMT2A | |
| SCHEMBL22122438 | 0.78 | GABRA1 (0.56) | MAPTKDM4ERECQLL3MBTL1GABRA1 | |
| SCHEMBL2303443 | 0.78 | CA12 (0.44) | ALDH1A1TSHR | |
| SCHEMBL8571647 | 0.78 | MMP8 (0.44) | SMN1; SMN2MMP8ALDH1A1MEN1KMT2A | |
| SCHEMBL8568021 | 0.77 | CYP3A4 (0.40) | SMN1; SMN2MMP8ALDH1A1MAPTMAPK1 | |
| SCHEMBL22122374 | 0.76 | LMNA (0.58) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8437061 | 0.76 | EPHX2 (0.49) | MMP8ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3909041 | 0.75 | ESR1 (0.46) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL3903766 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166002-A | Substituted phenylalkenoylguanidines, process for their preparation, and their use in medicaments and in diagnostics | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-26 | — | — | US | disclosed |
| US-6005010-A | CARDIOVASCULAR DISORDERS, ANTIARRHYTHMIA AGENTS AND ANTIISCHEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-21 | — | — | US | disclosed |