Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219083 | 0.87 | NAMPT (0.40) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL11926888 | 0.85 | KIF11 (0.43) | PTGS2TRPV1IGF1R | |
| SCHEMBL8214017 | 0.85 | CYP3A4 (0.43) | PTGS2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8215290 | 0.85 | PIK3CD (0.46) | RAB9AIGF1R | |
| SCHEMBL8214559 | 0.84 | EPHX2 (0.41) | CYP3A4CYP2D6CYP2C9CYP2C19CA12 | |
| SCHEMBL8211453 | 0.84 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP2C9CYP2C19CA12 | |
| SCHEMBL8218995 | 0.84 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP2C9CYP2C19CA12 | |
| SCHEMBL8217047 | 0.84 | EPHX1 (0.46) | CYP3A4CYP2D6CYP2C9CYP2C19CA12 | |
| SCHEMBL8219081 | 0.83 | NAMPT (0.43) | RAB9AIGF1R | |
| SCHEMBL8214025 | 0.83 | EPHX1 (0.47) | PTGS2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |