Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | DDX3X | O00571 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926888 | 0.91 | KIF11 (0.43) | NAMPTIGF1R | |
| SCHEMBL8215290 | 0.90 | PIK3CD (0.46) | NAMPTPIK3CAMTORPIK3CGIGF1R | |
| SCHEMBL8219081 | 0.89 | NAMPT (0.43) | NAMPTPIK3CAMTORIGF1RDDX3X | |
| SCHEMBL8217609 | 0.87 | PTGS2 (0.41) | IGF1RCA1CA2CA9CA12 | |
| SCHEMBL8215294 | 0.86 | NAMPT (0.42) | NAMPTPIK3CAMTORPIK3CGDDX3X | |
| SCHEMBL8205334 | 0.83 | PIK3CA (0.41) | NAMPTPIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8215440 | 0.83 | KMT2A (0.43) | NAMPTPIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8204669 | 0.82 | KMT2A (0.45) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8214220 | 0.82 | PIK3CA (0.48) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8214031 | 0.81 | ALDH1A1 (0.46) | PIK3CAMTORPIK3CGKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |