Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | DDX3X | O00571 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215290 | 0.91 | PIK3CD (0.46) | NAMPTPIK3CAMTORDDX3XPIK3CD | |
| SCHEMBL8215294 | 0.91 | NAMPT (0.42) | NAMPTPIK3CAMTORDDX3XKMT2A | |
| SCHEMBL8219083 | 0.89 | NAMPT (0.40) | NAMPTPIK3CAMTORDDX3XPIK3CD | |
| SCHEMBL11926888 | 0.87 | KIF11 (0.43) | NAMPTIGF1R | |
| SCHEMBL8217617 | 0.84 | PIK3CA (0.41) | NAMPTPIK3CAMTORPIK3CDKDR | |
| SCHEMBL11925440 | 0.84 | CA2 (0.42) | NAMPTPIK3CAMTORPIK3CDMEN1 | |
| SCHEMBL8213413 | 0.84 | PIK3CA (0.45) | NAMPTPIK3CAMTORPIK3CDKDM4E | |
| SCHEMBL8217609 | 0.83 | PTGS2 (0.41) | RAB9AIGF1R | |
| SCHEMBL8217050 | 0.83 | NAMPT (0.42) | NAMPTPIK3CAMTORPIK3CD | |
| SCHEMBL3588337 | 0.81 | PIK3CA (0.65) | PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |