Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219081 | 0.91 | NAMPT (0.43) | PIK3CDPIK3CANAMPTMTORDDX3X | |
| SCHEMBL8219083 | 0.90 | NAMPT (0.40) | PIK3CDPIK3CANAMPTMTORPIK3CG | |
| SCHEMBL8215294 | 0.89 | NAMPT (0.42) | PIK3CANAMPTMTORPIK3CGDDX3X | |
| SCHEMBL11926888 | 0.88 | KIF11 (0.43) | NAMPTIGF1R | |
| SCHEMBL8217609 | 0.85 | PTGS2 (0.41) | RAB9AIGF1R | |
| SCHEMBL8205332 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CANAMPTMTORPIK3CG | |
| SCHEMBL8205299 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CANAMPTMTORPIK3CG | |
| SCHEMBL8214526 | 0.83 | PIK3CD (0.61) | PIK3CDPIK3CAMTORPIK3CGGHSR | |
| SCHEMBL8213062 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3CANAMPTMTORPIK3CG | |
| SCHEMBL3594865 | 0.80 | PIK3CA (0.76) | PIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |