Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799718 | 0.82 | METAP2 (0.39) | METAP2ALDH1A1HCAR2KAT6AMEN1 | |
| SCHEMBL423355 | 0.78 | MEN1 (0.41) | METAP2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6418751 | 0.78 | CES2 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22980390 | 0.76 | DPP4 (0.47) | ALDH1A1 | |
| SCHEMBL9723219 | 0.74 | GABRA1 (0.32) | — | |
| SCHEMBL16936690 | 0.74 | GPR17 (0.35) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30277141 | 0.74 | GPR17 (0.35) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11334922 | 0.74 | GABRA1 (0.45) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL24908622 | 0.74 | RIPK1 (0.41) | METAP2ALDH1A1HCAR2MEN1KMT2A | |
| SCHEMBL9955505 | 0.74 | CA12 (0.48) | ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |