Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.43 |
| ▸ | AQP1 | P29972 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220451 | 0.92 | SLC6A2 (0.46) | SLC6A4SLC6A2SLC6A3AQP1 | |
| SCHEMBL14364276 | 0.91 | HTR7 (0.42) | SLC6A4SLC6A2SLC6A3AQP1ADRA1D | |
| SCHEMBL8220862 | 0.88 | AQP1 (0.38) | SLC6A4SLC6A2SLC6A3AQP1ADRA1D | |
| SCHEMBL4962508 | 0.88 | ADRA1D (0.45) | SLC6A4SLC6A2SLC6A3ADRA1DADRA1A | |
| SCHEMBL8221249 | 0.86 | ADRA1D (0.41) | SLC6A4SLC6A2SLC6A3ADRA1DADRA1A | |
| SCHEMBL8225821 | 0.84 | AQP1 (0.40) | SLC6A4SLC6A2SLC6A3AQP1 | |
| SCHEMBL8220442 | 0.81 | AQP1 (0.50) | SLC6A4SLC6A2SLC6A3AQP1 | |
| SCHEMBL8225835 | 0.81 | AQP1 (0.43) | AQP1HTR1ACA2 | |
| SCHEMBL8221211 | 0.81 | ADRA1D (0.45) | SLC6A4SLC6A2SLC6A3ADRA1DADRA1A | |
| SCHEMBL8221231 | 0.81 | AQP1 (0.41) | AQP1HTR1ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007123942-A2 | BENZODIOXANE AND BENZODIOXOLANE DERIVATIVES AND USES THEREOF | WYETH (US) | 2007-11-01 | — | — | WO | disclosed |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | HTR2C, HTR1D, HTR1A | SLC6A4 213/4885SLC6A2 262/4885SLC6A3 137/4885 |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | TBXA2R, HTR2C, NPY1R | SLC6A4 290/4885SLC6A2 353/4885SLC6A3 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.