Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741620 | 0.83 | ALDH1A1 (0.59) | EPHX2NR1H4KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4663159 | 0.79 | LOXL2 (0.56) | KMT2AMEN1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL5276387 | 0.77 | PARP10 (0.50) | PLA2G10PLA2G2APARP10EPHX2NR1H4 | |
| SCHEMBL10910029 | 0.76 | ESR1 (0.42) | KDM4ECA2ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL2033357 | 0.76 | FDPS (0.42) | HDAC1MAPK1ALDH1A1MAOBCYP3A4 | |
| SCHEMBL3249156 | 0.76 | HRH3 (0.43) | HDAC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL178439 | 0.76 | ALDH1A1 (0.64) | PLA2G10PLA2G2APARP10EPHX2NR1H4 | |
| SCHEMBL2464783 | 0.72 | PLK1 (0.60) | PLA2G10PLA2G2APARP10KMT2AKDM4E | |
| SCHEMBL28151928 | 0.72 | PLA2G10 (0.53) | PLA2G10PLA2G2APARP10EPHX2NR1H4 | |
| SCHEMBL7809399 | 0.72 | HDAC8 (0.64) | PLA2G10PLA2G2APARP10PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010985-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |