Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225015 | 0.86 | ACE (0.49) | ACERENF2 | |
| SCHEMBL13332259 | 0.84 | HDAC1 (0.30) | — | |
| SCHEMBL12820516 | 0.81 | HDAC4 (0.42) | ACEACE2RENPRCPKDM4E | |
| SCHEMBL2457111 | 0.79 | TGM2 (0.42) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL2457118 | 0.79 | TGM2 (0.42) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL8221483 | 0.79 | PRCP (0.42) | ACEACE2SMN1; SMN2PRCPPEPD | |
| SCHEMBL8005012 | 0.78 | ITGB3 (0.45) | ACEF2PEPD | |
| SCHEMBL13766136 | 0.78 | ITGB3 (0.47) | ACEF2 | |
| SCHEMBL8223113 | 0.78 | ITGB3 (0.43) | ACESMN1; SMN2F2 | |
| SCHEMBL13924274 | 0.78 | HDAC1 (0.46) | ACEF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057208-A2 | HCV NS3 PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2008-05-15 | — | — | WO | disclosed |