Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.39 |
| ▸ | PPID | Q08752 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.35 |
| ▸ | CPB1 | P15086 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227342 | 0.86 | FOLH1 (0.52) | SIRT6SIRT1FOLH1CPB2 | |
| SCHEMBL7911445 | 0.86 | FOLH1 (0.52) | SIRT6SIRT1FOLH1CPB2 | |
| SCHEMBL8201903 | 0.85 | KMT2A (0.49) | SIRT6SIRT1KMT2APOLBNOD1 | |
| SCHEMBL8193137 | 0.85 | SIRT1 (0.39) | SIRT6SIRT1FOLH1KMT2APOLB | |
| SCHEMBL8193831 | 0.79 | CYP1A2 (0.50) | KMT2APOLBTSHR | |
| SCHEMBL8201070 | 0.77 | NOD1 (0.39) | SIRT6SIRT1KMT2APOLBNOD1 | |
| SCHEMBL8193777 | 0.77 | DPP7 (0.43) | CPB2NOD1TSHR | |
| SCHEMBL12193061 | 0.77 | EPHX1 (0.56) | SIRT6SIRT1FOLH1KMT2ANOD1 | |
| SCHEMBL8206011 | 0.74 | DRD1 (0.46) | SIRT6SIRT1FOLH1PPID | |
| SCHEMBL7912042 | 0.73 | FOLH1 (0.43) | SIRT6SIRT1FOLH1CPB2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | claimed |