Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14885473 | 1.00 | GRM6 (0.43) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL25332623 | 0.94 | CYP2D6 (0.43) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL25332617 | 0.94 | CYP2D6 (0.43) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL25332628 | 0.93 | CYP2D6 (0.42) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL25332625 | 0.93 | CYP2D6 (0.42) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL17973110 | 0.83 | CYP2D6 (0.37) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL8142711 | 0.81 | GBA1 (0.46) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL14959515 | 0.79 | SIGMAR1 (0.42) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL12187945 | 0.79 | SIGMAR1 (0.42) | GRM6GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL16716374 | 0.78 | SIGMAR1 (0.41) | GRM6GBA1SIGMAR1SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794593-B1 | SPIRO AMINIC COMPOUNDS AS OREXIN ANTAGONISTS | Rottapharm Biotech Srl (IT) | 2017-02-01 | — | — | EP | disclosed |
| US-8921573-B2 | Processes for the preparation of novel benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140357653-A1 | CHEMICAL COMPOUNDS | ROTTAPHARM BIOTECH S.R.L. (IT) | 2014-12-04 | — | — | US | disclosed |
| US-20140316143-A1 | PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20120231998-A1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-09-13 | — | — | US | disclosed |
| US-20070286842-A1 | Organic Compounds and Their Uses | NOVARTIS AG (CH) | 2007-12-13 | — | — | US | disclosed |
| WO-2007133865-A2 | HCV/HIV INHIBITORS AN THEIR USES | NOVARTIS AG (CH) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070286842-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | GRM6 3317/4885GBA1 764/4885SIGMAR1 861/4885 |
| US-20140316143-A1 | PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES | MAVS, HAVCR2, EIF2AK2 | GRM6 4753/4885GBA1 654/4885SIGMAR1 3193/4885 |
| US-20120231998-A1 | ORGANIC COMPOUNDS AND THEIR USES | OAT, OTC, AOX1 | GRM6 3317/4885GBA1 764/4885SIGMAR1 861/4885 |
| US-20140357653-A1 | CHEMICAL COMPOUNDS | HCRTR2, HCRTR1, NPY1R | GRM6 1111/4885GBA1 1462/4885SIGMAR1 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.