Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222794 | 0.74 | GBA1 (0.40) | GBA1SLC6A2SLC6A4SLC6A3DDB1 | |
| SCHEMBL8225319 | 0.70 | OPRM1 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13657961 | 0.70 | ARG1 (0.41) | — | |
| SCHEMBL3910560 | 0.69 | MEN1 (0.37) | GBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8225299 | 0.69 | MEN1 (0.37) | GBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27475180 | 0.67 | GBA1 (0.51) | GBA1DDB1CRBN | |
| SCHEMBL323589 | 0.62 | GBA1 (0.46) | GBA1SLC6A2SLC6A4SLC6A3HDAC8 | |
| SCHEMBL8219841 | 0.61 | GBA1 (0.54) | GBA1SLC6A2SLC6A4SLC6A3DDB1 | |
| SCHEMBL1742163 | 0.61 | GBA1 (0.63) | GBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14246861 | 0.61 | GBA1 (0.40) | GBA1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |