Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156484 | 0.76 | CYP3A4 (0.47) | OPRM1L3MBTL1SMN1; SMN2GAALMNA | |
| SCHEMBL4156493 | 0.76 | CYP3A4 (0.47) | OPRM1L3MBTL1SMN1; SMN2GAALMNA | |
| SCHEMBL21807187 | 0.72 | SYK (0.44) | L3MBTL1SMN1; SMN2HTR2CMEN1KMT2A | |
| SCHEMBL4155702 | 0.72 | RORC (0.42) | L3MBTL1LMNAOPRD1OPRK1 | |
| SCHEMBL8913969 | 0.71 | OPRM1 (0.48) | OPRM1L3MBTL1SMN1; SMN2GAALMNA | |
| SCHEMBL8222794 | 0.71 | GBA1 (0.40) | GAASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3646187 | 0.70 | KDM4E (0.44) | OPRM1L3MBTL1GAALMNASLC6A4 | |
| SCHEMBL11662599 | 0.70 | L3MBTL1 (0.52) | OPRM1L3MBTL1SMN1; SMN2LMNASLC6A4 | |
| SCHEMBL8225218 | 0.70 | GBA1 (0.37) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28339181 | 0.68 | CYP2C19 (0.44) | OPRM1L3MBTL1SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |