Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910560 | 1.00 | MEN1 (0.37) | MEN1RAB9AKMT2AGBA1GRIN2B | |
| SCHEMBL8222794 | 0.79 | GBA1 (0.40) | GBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8225218 | 0.69 | GBA1 (0.37) | GBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27475180 | 0.66 | GBA1 (0.51) | GBA1 | |
| SCHEMBL8222704 | 0.65 | GBA1 (0.51) | MEN1RAB9AKMT2AGBA1GRIN2B | |
| SCHEMBL3913849 | 0.65 | GBA1 (0.51) | MEN1RAB9AKMT2AGBA1GRIN2B | |
| SCHEMBL8225319 | 0.63 | OPRM1 (0.44) | MEN1RAB9AKMT2ASLC6A2SLC6A4 | |
| SCHEMBL663239 | 0.61 | GRIN2B (0.74) | MEN1RAB9AKMT2AGRIN2BBCHE | |
| SCHEMBL25698481 | 0.60 | NOS3 (0.40) | GBA1 | |
| SCHEMBL3910981 | 0.60 | GBA1 (0.49) | GBA1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |