Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.57 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11199148 | 0.82 | LTB4R (0.46) | DAOLTB4RMAOAALDH1A1HPGD | |
| SCHEMBL28521994 | 0.78 | DAO (0.59) | DAOLTB4RMAOANOS1MAOB | |
| SCHEMBL27763564 | 0.77 | DAO (0.57) | DAOLTB4RMAOANOS1MAOB | |
| SCHEMBL1244006 | 0.77 | DAO (0.53) | DAOLTB4RMAOBMAPTNPC1 | |
| SCHEMBL13763150 | 0.77 | TSHR (0.52) | DAOMAOAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL1244005 | 0.76 | DAO (0.60) | DAOLTB4RMAOANOS1MAOB | |
| SCHEMBL21440071 | 0.73 | PRMT6 (0.42) | DAOALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL1243895 | 0.73 | DAO (0.57) | DAOLTB4RMAOANOS1MAOB | |
| SCHEMBL28528770 | 0.73 | DAO (0.57) | DAOLTB4RMAOANOS1MAOB | |
| SCHEMBL10966725 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |