Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.60 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114483 | 0.83 | LTB4R (0.56) | DAOLTB4RTSHRTDP1ADRA1D | |
| SCHEMBL28521994 | 0.77 | DAO (0.59) | DAOLTB4RTSHRTDP1NOS1 | |
| SCHEMBL27763564 | 0.76 | DAO (0.57) | DAOLTB4RTDP1NOS1ALDH1A1 | |
| SCHEMBL8225698 | 0.76 | DAO (0.57) | DAOLTB4RTDP1NOS1KDM4E | |
| SCHEMBL5110360 | 0.76 | LTB4R (0.53) | DAOLTB4RTSHR | |
| SCHEMBL20620966 | 0.75 | — | — | |
| SCHEMBL28528770 | 0.75 | DAO (0.57) | DAOLTB4RTDP1NOS1MAOA | |
| SCHEMBL5102999 | 0.75 | ALDH1A1 (0.38) | DAOLTB4RADRA1DADRA1AKDM4E | |
| SCHEMBL6495204 | 0.73 | TSHR (0.62) | DAOTSHRTDP1KDM4EALDH1A1 | |
| SCHEMBL3904348 | 0.73 | TSHR (0.78) | TSHRTDP1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| EP-2057162-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | Sepracor Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008005456-A2 | FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | DAO, DDO, AOX1 | DAO 1/4885LTB4R 2697/4885TSHR 4383/4885 |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | DAO 1/4885LTB4R 2658/4885TSHR 2483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.