Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | C1S | P09871 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11572214 | 0.78 | POLB (0.53) | GAATDP1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL11482485 | 0.78 | POLB (0.53) | GAATDP1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL11482477 | 0.78 | POLB (0.53) | GAATDP1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL22101827 | 0.77 | F2 (0.41) | GAAF2F10F12F7 | |
| SCHEMBL17068076 | 0.76 | CES2 (0.50) | GAANPSR1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL962604 | 0.72 | ALDH1A1 (0.48) | GAANPSR1TDP1MAPTPOLB | |
| SCHEMBL960634 | 0.70 | MAPT (0.61) | GAANPSR1TDP1PKMMAPT | |
| SCHEMBL14264702 | 0.70 | GAA (0.41) | GAANPSR1TDP1MAPTPOLB | |
| SCHEMBL960636 | 0.70 | MAPT (0.61) | GAANPSR1TDP1PKMMAPT | |
| SCHEMBL16814995 | 0.69 | F2 (0.58) | TDP1F2F10F12F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021871-A2 | TRIAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |