Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 5/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19275338 | 0.85 | PTGS2 (0.46) | MEN1NPC1LMNAHTTRAB9A | |
| SCHEMBL28880917 | 0.83 | RAPGEF4 (0.44) | MEN1NPC1LMNAHTTRAB9A | |
| SCHEMBL19275479 | 0.82 | PTGS2 (0.47) | MEN1NPC1LMNAHTTRAB9A | |
| SCHEMBL20898226 | 0.82 | TDP2 (0.47) | NPC1RAB9ASMN1; SMN2TDP2PTGS2 | |
| SCHEMBL14381080 | 0.82 | AKR1C2 (0.47) | NPC1RAB9ASMN1; SMN2PTGS2ERCC1 | |
| SCHEMBL256540 | 0.81 | — | — | |
| SCHEMBL1043172 | 0.80 | ESR2 (0.57) | NPC1RAB9ATDP2PTGS2ERCC1 | |
| SCHEMBL1047370 | 0.79 | AHR (0.70) | NPC1RAB9APGRAKR1C2AKR1C1 | |
| SCHEMBL12011026 | 0.79 | NFE2L2 (0.54) | PTGS2RAPGEF4PGRAKR1C2AR | |
| SCHEMBL265481 | 0.79 | NFE2L2 (0.54) | PTGS2RAPGEF4PGRAKR1C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140284-A2 | N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |