Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | NOS1 | P29475 | 4/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17053409 | 0.75 | MET (0.50) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL488782 | 0.74 | AHR (0.42) | BRD4 | |
| SCHEMBL8082211 | 0.74 | MET (0.49) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL14102482 | 0.69 | NOS1 (0.49) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL29376674 | 0.69 | IDO1 (0.50) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL189955 | 0.69 | IDO1 (0.50) | IDO1METAXLNOS1METAP2 | |
| Hydrochloric Acid SCHEMBL4683856 | 0.68 | NOS1 (0.47) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL31741677 | 0.68 | KDM4E (0.43) | IDO1 | |
| SCHEMBL4686484 | 0.68 | SLC6A4 (0.44) | IDO1METAXLNOS1METAP2 | |
| SCHEMBL4684070 | 0.67 | MET (0.45) | IDO1METAXLNOS1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |
| EP-2246354-A1 | Thieno[3,2-d]pyrimidine derivative useful as PI3K inhibitor | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| EP-2024372-B1 | THIENO[3,2-D]PYRIMIDINE DERIVATIVE USEFUL AS PI3K INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-06-23 | — | — | EP | disclosed |
| WO-2007129161-A2 | THIENO [3, 2-D] PYRIMIDINE DERIVATIVE USEFUL AS PI3K INHIBITOR | F. HOFFMANN-LA ROCHE AG (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007127175-A2 | PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007042806-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | LUDWIG INSTITUTE FOR CANCER RESEARCH (CH) | 2007-04-19 | — | — | WO | disclosed |