Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4683856 | 0.98 | NOS1 (0.47) | NOS1AXLMETIDO1METAP2 | |
| SCHEMBL22619200 | 0.87 | NOS1 (0.44) | NOS1AXLMETIDO1METAP2 | |
| Trifluoroacetic Acid SCHEMBL4687032 | 0.86 | TRPV1 (0.44) | AXLTRPV1 | |
| SCHEMBL7775075 | 0.85 | HTR2A (0.43) | NOS1AXLMETTRPV1 | |
| SCHEMBL17053409 | 0.79 | MET (0.50) | NOS1AXLMETIDO1METAP2 | |
| SCHEMBL3671316 | 0.76 | TRPV1 (0.47) | NOS1AXLMETIDO1TRPV1 | |
| SCHEMBL4684070 | 0.76 | MET (0.45) | NOS1AXLMETIDO1METAP2 | |
| SCHEMBL22808947 | 0.75 | MET (0.44) | NOS1AXLMETIDO1METAP2 | |
| SCHEMBL4686484 | 0.74 | SLC6A4 (0.44) | NOS1AXLMETIDO1METAP2 | |
| SCHEMBL8082211 | 0.74 | MET (0.49) | NOS1AXLMETIDO1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753763-B1 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PFIZER LTD (GB) | 2008-08-13 | — | — | EP | disclosed |