Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235484 | 0.88 | NR4A2 (0.56) | NR4A2KCNH2CYP17A1CYP3A4MAPT | |
| SCHEMBL10475891 | 0.88 | CYP17A1 (0.35) | NR4A2KCNH2CYP17A1CYP3A4F2 | |
| SCHEMBL8229276 | 0.79 | NR4A2 (0.42) | NR4A2MAPTRXRARXRBMAPK1 | |
| SCHEMBL10475895 | 0.79 | FYN (0.54) | MAPTPGRKDR | |
| SCHEMBL2031842 | 0.78 | KMO (0.44) | RXRARXRB | |
| SCHEMBL8236991 | 0.78 | FYN (0.42) | NR4A2KCNH2CNR2 | |
| SCHEMBL2032459 | 0.76 | FYN (0.46) | KCNH2 | |
| SCHEMBL2029037 | 0.76 | TDP2 (0.45) | NR4A2MAPT | |
| SCHEMBL12543892 | 0.76 | GABRG2 (0.49) | CNR2MAPT | |
| SCHEMBL8230154 | 0.76 | TRIM24 (0.42) | MAPTMAPK1HTTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477990-B1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-08-20 | — | — | EP | claimed |
| US-8618301-B2 | 5-phenylpyrazolopyridine derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-12-31 | — | — | US | claimed |
| US-20130023554-A1 | 5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-01-24 | — | — | US | claimed |
| EP-2477990-B1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-08-20 | — | — | EP | disclosed |
| US-8618301-B2 | 5-phenylpyrazolopyridine derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-12-31 | — | — | US | disclosed |
| US-20130023554-A1 | 5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| EP-2477990-A1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033230-A1 | 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023554-A1 | 5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | CBR3, CBR1, OGFR | NR4A2 296/4885KCNH2 64/4885CYP17A1 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.