Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001084 | 1.00 | GAA (0.55) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL4413307 | 0.87 | GAA (0.69) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL3273659 | 0.87 | GAA (0.69) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL13345208 | 0.87 | GAA (0.69) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL11325414 | 0.84 | MAPT (0.60) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL11726036 | 0.84 | MEN1 (0.57) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL15187708 | 0.84 | RAB9A (0.57) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL8230499 | 0.83 | ALDH1A1 (0.71) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL22160190 | 0.82 | ALDH1A1 (0.71) | GAAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL11728616 | 0.82 | GAA (0.55) | GAAMEN1KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263624-B2 | Aryl-substituted heterocycles, and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-09-11 | — | — | US | disclosed |
| US-8263624-B2 | Aryl-substituted heterocycles, and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-09-11 | — | — | US | disclosed |
| US-20110015241-A1 | SUBSTITUTED HETEROCYCLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-01-20 | — | — | US | disclosed |
| US-20110015241-A1 | SUBSTITUTED HETEROCYCLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-01-20 | — | — | US | disclosed |
| EP-2029546-B1 | ARYL-SUBSTITUTED HETEROCYCLES, AND USE THEREOF | BAYER SCHERING PHARMA AG (DE) | 2010-07-28 | — | — | EP | disclosed |
| US-20100029651-A1 | ARYL-SUBSTITUTED HETEROCYCLES, AND USE THEREOF | BAYER HEALTHCARE AG | 2010-02-04 | — | — | US | disclosed |
| US-20100029651-A1 | ARYL-SUBSTITUTED HETEROCYCLES, AND USE THEREOF | BAYER HEALTHCARE AG | 2010-02-04 | — | — | US | disclosed |
| WO-2007137791-A1 | ARYL-SUBSTITUTED HETEROCYCLES, AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007137792-A1 | SUBSTITUTED HETEROCYCLES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015241-A1 | SUBSTITUTED HETEROCYCLES AND USE THEREOF | F2, VKORC1, HMBS | GAA 797/4885MEN1 366/4885KMT2A 2803/4885 |
| US-20100029651-A1 | ARYL-SUBSTITUTED HETEROCYCLES, AND USE THEREOF | AHR, CYP2C19, PAH | GAA 705/4885MEN1 620/4885KMT2A 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.