SCHEMBL822923

SCHEMBL822923

COc1ccc(C23CC4CC(C2)CC(c2ccc(OC(C)=O)cc2)(C4)C3)cc1

nearest known ligand 0.60

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
HSD11B1 P28845 2/20 0.55
PGR P06401 4/20 0.48
ESR1 P03372 1/20 0.47
KMT2A Q03164 4/20 0.45
MEN1 O00255 3/20 0.45
EPHX2 P34913 1/20 0.45
CNR2 P34972 1/20 0.45
RAB9A P51151 1/20 0.45
NPC1 O15118 1/20 0.44
GAA P10253 1/20 0.44
RECQL P46063 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16352314 0.88 LMNA (0.56) LMNASMN1; SMN2HSD11B1PGRESR1
SCHEMBL8766728 0.88 LMNA (0.56) LMNASMN1; SMN2HSD11B1PGRESR1
SCHEMBL2721139 0.85 NPC1 (0.59) LMNAKMT2AMEN1EPHX2RAB9A
SCHEMBL12276579 0.82 SMN1; SMN2 (0.65) LMNASMN1; SMN2HSD11B1ESR1KMT2A
SCHEMBL18028223 0.82 GRIN2D (0.46) LMNASMN1; SMN2HSD11B1KMT2AMEN1
SCHEMBL12936217 0.82 KMT2A (0.66) LMNASMN1; SMN2HSD11B1KMT2AMEN1
SCHEMBL8767208 0.79 LMNA (0.52) LMNASMN1; SMN2HSD11B1PGRESR1
SCHEMBL14175565 0.78 HSD11B1 (0.57) LMNAHSD11B1KMT2AEPHX2CNR2
SCHEMBL12040557 0.78 LMNA (0.57) LMNASMN1; SMN2HSD11B1KMT2AMEN1
SCHEMBL13144077 0.77 HPGD (0.43) LMNAHSD11B1KMT2AEPHX2CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8535862-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-09-17 US disclosed
US-8518618-B2 Electrophotographic photoconductor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-08-27 US disclosed
US-20120009513-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-01-12 US disclosed
US-20120008978-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-01-12 US disclosed
US-7329718-B2 Aromatic polycarbonate resin, process for producing the same, optical-part molding material, and optical part IDEMITSU KOSAN CO., LTD. (JP) 2008-02-12 US disclosed