Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649504 | 0.90 | ALDH1A1 (0.41) | TP53HTTGAAKMT2ANPC1 | |
| SCHEMBL8234476 | 0.88 | HPGD (0.41) | KMT2AEGFRKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8235951 | 0.88 | SMN1; SMN2 (0.38) | TP53GAAEGFRKDM4ESMN1; SMN2 | |
| SCHEMBL8236420 | 0.86 | MAPT (0.46) | KMT2AEGFRKDM4ENPC1RAB9A | |
| SCHEMBL11940274 | 0.85 | IL2 (0.41) | TP53GAAKMT2AEGFRKDM4E | |
| SCHEMBL8233863 | 0.85 | EPHX2 (0.42) | TP53EGFRKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL8236756 | 0.84 | NPC1 (0.46) | TP53GAAKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL8233835 | 0.84 | LOXL2 (0.39) | TP53GAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8236393 | 0.84 | IL2 (0.41) | TP53GAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8233948 | 0.83 | GRM5 (0.44) | EGFRKDM4ENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109362-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-27 | — | — | WO | disclosed |