Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | GLS | O94925 | 14/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10163496 | 0.96 | ADAMTS4 (0.43) | ROCK2GLSMMP13ADAMTS4MMP3 | |
| SCHEMBL8226602 | 0.94 | MMP13 (0.42) | ROCK2MMP13ADAMTS4MMP3MAPK1 | |
| SCHEMBL10163505 | 0.91 | MMP13 (0.40) | ROCK2MMP13ADAMTS4MMP3ROCK1 | |
| SCHEMBL10163503 | 0.90 | MMP13 (0.42) | MMP13ADAMTS4MMP3 | |
| SCHEMBL8225568 | 0.89 | MMP13 (0.43) | ROCK2MMP13ADAMTS4MMP3MAPK1 | |
| SCHEMBL10163488 | 0.89 | MMP13 (0.44) | MMP13ADAMTS4MMP3 | |
| SCHEMBL8228853 | 0.89 | ADAMTS4 (0.40) | MMP13ADAMTS4MMP3MAPK1 | |
| SCHEMBL10163455 | 0.88 | POLB (0.45) | MMP13ADAMTS4MMP3 | |
| SCHEMBL8222865 | 0.87 | MMP13 (0.44) | MMP13ADAMTS4MMP3MAPK1 | |
| SCHEMBL10163509 | 0.87 | MMP13 (0.41) | ROCK2MMP13ADAMTS4MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |