Sugi Predict

Sugi Predict / Compounds / SCHEMBL10163455

SCHEMBL10163455

SCHEMBL10163455

Cc1cccc(CNC(=O)c2cc(C(=O)NCc3ccc4oc(=O)n(C)c4c3)nc3c(F)cnn23)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.45
▸ MMP13 P45452 3/20 0.44
▸ ADAMTS4 O75173 1/20 0.44
▸ MMP3 P08254 1/20 0.44
▸ TP53 P04637 4/20 0.38
▸ ADORA2A P29274 2/20 0.38
▸ ADORA1 P30542 2/20 0.38
▸ ADORA3 P0DMS8 1/20 0.38
▸ ADORA2B P29275 1/20 0.38
▸ LMNA P02545 4/20 0.38
▸ MAPT P10636 3/20 0.38
▸ RXFP1 Q9HBX9 3/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ THRB P10828 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ NR3C1 P04150 1/20 0.37
▸ ASAH1 Q13510 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8225568 0.93 MMP13 (0.43) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL10163488 0.93 MMP13 (0.44) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL10163453 0.93 L3MBTL1 (0.45) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL10163509 0.91 MMP13 (0.41) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL8225501 0.91 MMP13 (0.48) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL10163512 0.91 MMP13 (0.43) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL8225565 0.90 TP53 (0.43) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL10210575 0.90 ADAMTS4 (0.41) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL8226089 0.90 MMP13 (0.41) POLBMMP13ADAMTS4MMP3TP53
SCHEMBL8221168 0.90 MMP13 (0.43) POLBMMP13ADAMTS4MMP3ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835441-B2 Heterobicyclic metalloprotease inhibitors AMGEN INC. (US) 2014-09-16 — — US disclosed
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2012-01-19 — — US disclosed
US-7795245-B2 Heterobicyclic metalloprotease inhibitors Atlantos Pharmaceuticals Holding, Inc. (US) 2010-09-14 — — US disclosed
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-12-17 — — US disclosed
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. 2009-05-28 — — US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors MMP13, TIMP3, MMP3 POLB 1285/4885MMP13 1/4885ADAMTS4 38/4885
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS MMP13, TIMP3, MMP3 POLB 1285/4885MMP13 1/4885ADAMTS4 38/4885
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 POLB 1285/4885MMP13 1/4885ADAMTS4 38/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 POLB 1285/4885MMP13 1/4885ADAMTS4 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.