Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10163503 | 0.95 | MMP13 (0.42) | MMP13ADAMTS4MMP3ADRB2PDE2A | |
| SCHEMBL8229799 | 0.94 | ROCK2 (0.44) | MMP13ADAMTS4MMP3MAPK1ROCK2 | |
| SCHEMBL8225565 | 0.90 | TP53 (0.43) | MMP13ADAMTS4MMP3SMN1; SMN2KMT2A | |
| SCHEMBL8226631 | 0.90 | MMP13 (0.40) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL10163504 | 0.90 | MMP13 (0.40) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL8222865 | 0.89 | MMP13 (0.44) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL8228853 | 0.89 | ADAMTS4 (0.40) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL10163488 | 0.89 | MMP13 (0.44) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL10163453 | 0.89 | L3MBTL1 (0.45) | MMP13ADAMTS4MMP3ALDH1A1SMN1; SMN2 | |
| SCHEMBL10163496 | 0.89 | ADAMTS4 (0.43) | MMP13ADAMTS4MMP3MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |