Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583381 | 0.93 | PTPRB (0.41) | PTPRBSCN9ACYP3A4PDPK1CCNB2 | |
| SCHEMBL8240525 | 0.91 | SCN9A (0.36) | PTPRBSCN9ACYP3A4PDPK1CCNB2 | |
| SCHEMBL8234181 | 0.90 | PDPK1 (0.33) | PDPK1CCNB2PRKCBCDK1LYN | |
| SCHEMBL8241863 | 0.88 | ELANE (0.38) | PDPK1CCNB2PRKCBCDK1LYN | |
| SCHEMBL8233323 | 0.81 | HTR6 (0.39) | PDPK1CCNB2PRKCBCDK1LYN | |
| SCHEMBL4592468 | 0.76 | ELANE (0.36) | PDPK1CDK2ELANEHTR6 | |
| SCHEMBL8233595 | 0.73 | RORC (0.39) | PDPK1CCNB2PRKCBCDK1LYN | |
| SCHEMBL8240354 | 0.73 | AKT1 (0.40) | SCN9APDPK1CCNB2PRKCBCDK1 | |
| SCHEMBL4584006 | 0.72 | HTR6 (0.41) | CDK2PIK3C3HTR6 | |
| SCHEMBL8240222 | 0.70 | RORC (0.42) | PIK3C3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |