Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 6/20 | 0.32 |
| ▸ | AKT2 | P31751 | 3/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241863 | 0.76 | ELANE (0.38) | ELANEHTR6PTGDR2PDPK1CCNE1 | |
| SCHEMBL8233291 | 0.76 | PTPRB (0.37) | ELANEHTR6PDPK1CDK2 | |
| SCHEMBL4583354 | 0.72 | HTR6 (0.42) | HTR6PTGDR2CCNE1CDK2CCNC | |
| SCHEMBL8234181 | 0.71 | PDPK1 (0.33) | ELANEHTR6AKT1PDPK1CDK2 | |
| SCHEMBL4584230 | 0.70 | AKT1 (0.48) | HTR6AKT1AKT2AKT3 | |
| SCHEMBL4441518 | 0.70 | KMT2A (0.37) | — | |
| SCHEMBL4554084 | 0.68 | CTSL (0.36) | — | |
| SCHEMBL4584006 | 0.68 | HTR6 (0.41) | HTR6PTGDR2CCNE1CDK2CCNC | |
| SCHEMBL4584368 | 0.68 | AKT1 (0.59) | AKT1AKT2AKT3 | |
| SCHEMBL4583381 | 0.67 | PTPRB (0.41) | HTR6PDPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |