Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234988 | 0.91 | MAPK14 (0.40) | RORBMAPK14KMT2ATRPM8KDM1A | |
| SCHEMBL8236060 | 0.91 | RORB (0.42) | RORBMAPK14KMT2ATRPM8KDM1A | |
| SCHEMBL8245942 | 0.91 | RORB (0.42) | RORBMAPK14KMT2ATRPM8KDM1A | |
| SCHEMBL8238504 | 0.89 | RORB (0.47) | RORBMAPK14KMT2AKMOSMN1; SMN2 | |
| SCHEMBL8285415 | 0.86 | PTGDR2 (0.41) | RORBMAPK14KMT2ATRPM8ADORA2A | |
| SCHEMBL8294963 | 0.86 | PTGDR2 (0.41) | RORBMAPK14KMT2ATRPM8ADORA2A | |
| SCHEMBL8304829 | 0.84 | PTGDR2 (0.38) | RORBMAPK14KMT2AADORA2AADORA1 | |
| SCHEMBL8235754 | 0.80 | RORB (0.47) | RORBMAPK14KMT2ATRPM8KDM1A | |
| SCHEMBL8301479 | 0.79 | PTGDR2 (0.42) | ADORA2AADORA1PIN1PDE4APDE4C | |
| SCHEMBL8309906 | 0.78 | PTGDR2 (0.43) | ADORA2AADORA1PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467381-B1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND THIER USE FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO KG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2467381-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011020822-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2011-02-24 | — | — | WO | disclosed |