SCHEMBL82380

SCHEMBL82380

COc1cccc(C2=NC(c3ccccc3Cl)(C3(c4ccccc4Cl)N=C(c4cccc(OC)c4)C(c4cccc(OC)c4)=N3)N=C2c2cccc(OC)c2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
MAPT P10636 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
TP53 P04637 2/20 0.40
GAA P10253 1/20 0.40
TDP1 Q9NUW8 3/20 0.40
ADORA2A P29274 2/20 0.40
ADORA1 P30542 2/20 0.40
NFKB1 P19838 2/20 0.40
RAB9A P51151 2/20 0.40
NFKB2 Q00653 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29660677 1.00 DYRK1A (0.43) DYRK1ACLK4CASP3SENP8SENP7
SCHEMBL8861300 0.90 DYRK1A (0.42) DYRK1ACLK4CASP3SENP8SENP7
SCHEMBL5702288 0.84 PGR (0.35) DYRK1ACLK4CASP3SENP8SENP7
SCHEMBL8666635 0.84 DYRK1A (0.44) DYRK1ACLK4MAPTSMN1; SMN2TP53
SCHEMBL11268438 0.84 ALDH1A1 (0.43) MAPTTDP1RAB9ARELANPC1
SCHEMBL490794 0.84 RELA (0.40) CLK4MAPTSMN1; SMN2GAATDP1
SCHEMBL29417503 0.83 DYRK1A (0.43) DYRK1ACLK4MAPTSMN1; SMN2TP53
SCHEMBL6941655 0.83 DYRK1A (0.43) DYRK1ACLK4MAPTSMN1; SMN2TP53
SCHEMBL18887138 0.81 CYP1A2 (0.39) CLK4MAPTSMN1; SMN2PDE4APDE4B
SCHEMBL9356793 0.81 DYRK1A (0.39) DYRK1ACLK4CASP3SENP8SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060154169-A1 Radiation-sensitive compositions comprising a 1,4-dihydropyridine sensitizer and imageable elements based thereon KODAK POLYCHROME GRAPHICS GMBH (DE) 2006-07-13 US claimed
WO-2004111731-A1 RADIATION-SENSITIVE COMPOSITIONS COMPRISING A 1,4-DIHYDROPYRIDINE SENSITIZER AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-12-23 WO claimed
EP-1062546-A1 PROCESS FOR THE CONTINUOUS LIQUID PROCESSING OF PHOTOSENSITIVE COMPOSITIONS HAVING REDUCED LEVELS OF RESIDUES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2000-12-27 EP claimed
WO-1999046644-A1 PROCESS FOR THE CONTINUOUS LIQUID PROCESSING OF PHOTOSENSITIVE COMPOSITIONS HAVING REDUCED LEVELS OF RESIDUES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-09-16 WO claimed
EP-0520364-B1 Photopolymerizable composition FUJI PHOTO FILM CO LTD (JP) 1997-09-17 EP claimed
EP-0377321-B1 Photopolymerizable composition FUJI PHOTO FILM CO LTD (JP) 1995-03-22 EP claimed
US-5385807-A Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1995-01-31 US claimed
US-5288528-A Decomposing, repolymerizing additoin polymers; chain transfer agent or initiator present; molecular weight control E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-02-22 US claimed
EP-0520364-A1 Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1992-12-30 EP claimed
US-5049481-A Merocyanine compound FUJI PHOTO FILM CO., LTD. (JP) 1991-09-17 US claimed
EP-0377321-A2 Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1990-07-11 EP claimed
US-4859551-A Process for preparing positive and negative images using photohardenable electrostatic master E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-08-22 US claimed
US-4849314-A PHOTOPOLYMERIZATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-18 US claimed
US-4837106-A Recording materials containing photopolymerizable composition and component capable of causing a color reaction in microcapsules FUJI PHOTO FILM CO., LTD. (JP) 1989-06-06 US claimed
EP-0315116-A2 Photohardenable electrostatic master containing electron acceptor or donor E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-05-10 EP claimed
EP-0315121-A2 Process for preparing positive and negative images using photohardenable electrostatic master E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-05-10 EP claimed
EP-0019219-B1 IMPROVED PHOTOIMAGING SYSTEMS WITH CYCLIC HYDRAZIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-06-22 EP claimed
US-4271260-A POSITIVE IMAGES OBTAINED USING A SUPPORTED LAYER OF AN ALKALI-SOLUBLE POLYMERIC BINDER, A HEXAARYLBIIMIAZOLE, AND A CARBOXY-, CARBONYL-, OR CYANO-SUBSTITUTED DIHYDROPYRIDINE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-02 US claimed
US-4247618-A LEUCO DYES, PHOTOOXIDANT E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-01-27 US claimed
EP-0019219-A1 Improved photoimaging systems with cyclic hydrazides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1980-11-26 EP claimed