Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234112 | 0.91 | TP53 (0.45) | RAB9ANPC1HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL8234439 | 0.90 | TP53 (0.45) | HSP90AA1HSP90AB1HSD17B10THRBGSK3B | |
| SCHEMBL8238176 | 0.89 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1HSD17B10THRBKCNH2 | |
| SCHEMBL8233770 | 0.88 | TP53 (0.43) | HSP90AA1HSP90AB1HSD17B10THRBGSK3B | |
| SCHEMBL648772 | 0.87 | F10 (0.42) | RAB9ANPC1F2F10KCNH2 | |
| SCHEMBL8236747 | 0.86 | NPC1 (0.46) | RAB9ANPC1HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL8234043 | 0.86 | PLK1 (0.48) | RAB9ANPC1HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL8234051 | 0.83 | ALOX15 (0.49) | HSD17B10THRBMAPTTSHRNPSR1 | |
| SCHEMBL8234426 | 0.83 | RAB9A (0.45) | RAB9ANPC1HSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL8236417 | 0.83 | RAB9A (0.51) | RAB9ANPC1HSP90AA1HSP90AB1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109362-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-27 | — | — | WO | disclosed |