Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | VDR | P11473 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249384 | 0.84 | F2 (0.37) | F2F10PRSS1GAA | |
| SCHEMBL6382019 | 0.84 | F2 (0.37) | F2F10PRSS1GAA | |
| SCHEMBL11976295 | 0.84 | ADRB3 (0.45) | BACE1F2F10PRSS1REN | |
| SCHEMBL11984174 | 0.81 | ADRB3 (0.40) | BACE1RENADRB3ADRA2BADRA2C | |
| SCHEMBL8249390 | 0.79 | CYP3A4 (0.38) | ADRB3ADRA2BADRA2C | |
| SCHEMBL13886148 | 0.79 | REN (0.33) | BACE1RENADRB3ADRA2BADRA2C | |
| SCHEMBL8278256 | 0.79 | REN (0.33) | BACE1RENADRB3ADRA2BADRA2C | |
| SCHEMBL14561086 | 0.78 | ADRB3 (0.39) | ADRB3ADRA2BADRA2CNAAA | |
| SCHEMBL8294160 | 0.76 | DRD2 (0.35) | RENADRB3ADRA2BADRA2C | |
| SCHEMBL12785342 | 0.76 | GAA (0.39) | F2F10PRSS1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015824-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2007-02-08 | — | — | WO | disclosed |