Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5854414 | 0.87 | ADRB1 (0.54) | ADRB1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL4071866 | 0.81 | ADRB1 (0.50) | ADRB1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL1889513 | 0.80 | LMNA (0.46) | ADRB1MAPTMEN1KMT2APOLB | |
| SCHEMBL5276484 | 0.79 | SIGMAR1 (0.48) | ADRB1MAPTNPSR1KMT2AAKR1C3 | |
| SCHEMBL4317647 | 0.79 | MAPT (0.50) | MAPTNPSR1MEN1KMT2APOLB | |
| SCHEMBL4565389 | 0.79 | MAPK1 (0.48) | MAPTNPSR1MEN1KMT2APOLB | |
| SCHEMBL8263647 | 0.79 | ADRB1 (0.56) | ADRB1MAPTHTR7RAB9ADHFR | |
| SCHEMBL13105671 | 0.79 | IKBKB (0.41) | MAPTNPSR1MEN1KMT2AHTR7 | |
| SCHEMBL26814948 | 0.79 | ALDH1A1 (0.40) | MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7038234 | 0.79 | ADRB1 (0.53) | ADRB1MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |