Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10125001 | 0.84 | L3MBTL1 (0.49) | L3MBTL1MEN1KMT2ABRD4PKM | |
| SCHEMBL2237896 | 0.82 | L3MBTL1 (0.62) | L3MBTL1BRD4PKMCYP2C19POLB | |
| SCHEMBL12346678 | 0.79 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2ABRD4PKM | |
| SCHEMBL10125007 | 0.79 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2ABRD4PKM | |
| SCHEMBL1780348 | 0.79 | L3MBTL1 (0.55) | L3MBTL1METMEN1KMT2ABRD4 | |
| SCHEMBL14494739 | 0.78 | L3MBTL1 (0.43) | L3MBTL1BRD4PKMCYP2C19POLB | |
| SCHEMBL10125005 | 0.77 | L3MBTL1 (0.43) | L3MBTL1MEN1KMT2ABRD4PKM | |
| SCHEMBL8242402 | 0.76 | HTR6 (0.44) | METMEN1KMT2AALOX5CYP2A6 | |
| SCHEMBL1779961 | 0.75 | L3MBTL1 (0.57) | L3MBTL1BRD4PKMCYP2C19POLB | |
| SCHEMBL4318539 | 0.75 | L3MBTL1 (0.43) | L3MBTL1METMEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |