Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627473 | 0.77 | XDH (0.51) | XDHALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL24714540 | 0.76 | XDH (0.44) | XDHALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL3700367 | 0.74 | XDH (0.49) | XDHALDH1A1SMN1; SMN2LMNAMAPT | |
| Oxypurinol SCHEMBL8257647 | 0.73 | XDH (0.48) | XDHALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL24351056 | 0.72 | XDH (0.44) | XDHALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5765249 | 0.69 | HTT (0.41) | XDHALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL1847814 | 0.67 | CYP1A2 (0.41) | XDHLMNAFGFR1FLT1 | |
| SCHEMBL8219126 | 0.67 | NUDT1 (0.37) | XDHALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL1132916 | 0.67 | ALDH1A1 (0.44) | XDHALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8407639 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071524-A1 | 2-NH-PYRIDONES AND PYRIMIDONES AS MRS INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |