Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763588 | 0.79 | PARP1 (0.37) | PARP1KDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1441939 | 0.75 | HTT (0.49) | HTTPKMKMT2APARP1KDM4E | |
| SCHEMBL23160932 | 0.75 | HTT (0.47) | HTTPKMPOLBKMT2AKDM4E | |
| SCHEMBL5765110 | 0.69 | PARP1 (0.37) | PARP1 | |
| SCHEMBL8241597 | 0.69 | XDH (0.44) | HTTKMT2AMAPTXDHSMN1; SMN2 | |
| SCHEMBL25350548 | 0.65 | PKM (0.68) | HTTPKMPOLBKMT2AMAPT | |
| SCHEMBL1132916 | 0.64 | ALDH1A1 (0.44) | HTTPOLBKMT2APARP1KDM4E | |
| SCHEMBL1131992 | 0.62 | HPGD (0.58) | KMT2AKDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL9878843 | 0.62 | ADORA1 (0.44) | HTTPKMPOLBKMT2AKDM4E | |
| SCHEMBL8234838 | 0.61 | KMT2A (0.58) | POLBKMT2APARP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |