SCHEMBL8243456

SCHEMBL8243456

O=C(CCCCCN1C(=O)c2cccc3cccc(c23)C1O)NO

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 14/20 0.65
HDAC1 Q13547 14/20 0.65
HDAC3 O15379 13/20 0.65
HDAC11 Q96DB2 13/20 0.65
HDAC6 Q9UBN7 13/20 0.65
HDAC2 Q92769 12/20 0.65
HDAC7 Q8WUI4 11/20 0.65
HDAC10 Q969S8 11/20 0.65
HDAC5 Q9UQL6 11/20 0.65
HDAC4 P56524 10/20 0.65
HDAC9 Q9UKV0 10/20 0.65
NCOR2 Q9Y618 6/20 0.65
ALDH1A1 P00352 3/20 0.65
MEN1 O00255 1/20 0.65
LTA4H P09960 1/20 0.65
KMT2A Q03164 1/20 0.65
KDM4E B2RXH2 3/20 0.49
GAA P10253 1/20 0.49
HTT P42858 1/20 0.49
KCNH2 Q12809 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Scriptaid SCHEMBL29383029 0.79 HDAC8 (1.00) HDAC8HDAC1HDAC3HDAC11HDAC6
Scriptaid SCHEMBL780490 0.79 HDAC8 (1.00) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL5852563 0.76 HDAC8 (0.83) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL411511 0.74 ALDH1A1 (0.90) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL29382031 0.74 ALDH1A1 (0.90) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL24136240 0.74 HDAC8 (0.67) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL13935785 0.74 HDAC1 (0.51) HDAC8HDAC1HDAC3HDAC11HDAC6
SCHEMBL16213588 0.73 HEXA (0.58) ALDH1A1MEN1KMT2AKDM4EL3MBTL1
SCHEMBL11629868 0.73 SIGMAR1 (0.47) MEN1KMT2AL3MBTL1
SCHEMBL11631445 0.73 SIGMAR1 (0.47) MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007031853-A2 THERAPEUTIC COMBINATION OF HAMLET AND A HDAC INHIBITOR TO TREAT CANCER NYA HAMLET PHARMA AB (DK) 2007-03-22 WO disclosed