Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.85 |
| ▸ | CNR2 | P34972 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243863 | 0.90 | RAB9A (0.91) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL17074609 | 0.85 | CNR2 (0.81) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL17074595 | 0.83 | CNR2 (1.00) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL17074610 | 0.80 | SMN1; SMN2 (0.57) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL13219471 | 0.79 | HTT (0.78) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL17074605 | 0.79 | CNR2 (0.70) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL8246044 | 0.79 | RAB9A (0.56) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL8243861 | 0.77 | CA12 (0.62) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL8242081 | 0.76 | SMN1; SMN2 (0.73) | RAB9ASMN1; SMN2KDM4ECNR2HTT | |
| SCHEMBL19000705 | 0.76 | RAB9A (0.60) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2957560-A1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN, INC. (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2534137-B1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN INC (US) | 2015-09-16 | — | — | EP | disclosed |