Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 7/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219845 | 0.95 | NPC1 (0.61) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8221371 | 0.94 | NPC1 (0.60) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8235188 | 0.94 | NPC1 (0.60) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8219502 | 0.94 | PPARG (0.61) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8222773 | 0.94 | NPC1 (0.60) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8222800 | 0.93 | NPC1 (0.58) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8230191 | 0.92 | ADORA3 (0.58) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8216737 | 0.91 | NPC1 (0.56) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8215912 | 0.91 | NPC1 (0.56) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL8242012 | 0.90 | PPARG (0.57) | NPC1RAB9AADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877747-B2 | Indenone derivative and pharmaceutical composition comprising same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2014-11-04 | — | — | US | claimed |
| EP-2475649-B1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RES INST CHEM TECH (KR) | 2014-08-13 | — | — | EP | claimed |
| US-20120214991-A1 | Indenone Derivative and Pharmaceutical Composition Comprising Same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-08-23 | — | — | US | claimed |
| EP-2475649-A1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute Of Chemical Technology (KR) | 2012-07-18 | — | — | EP | claimed |
| WO-2011030955-A1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-03-17 | — | — | WO | claimed |
| US-8877747-B2 | Indenone derivative and pharmaceutical composition comprising same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2014-11-04 | — | — | US | disclosed |
| EP-2475649-B1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RES INST CHEM TECH (KR) | 2014-08-13 | — | — | EP | disclosed |
| US-20120214991-A1 | Indenone Derivative and Pharmaceutical Composition Comprising Same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-08-23 | — | — | US | disclosed |
| EP-2475649-A1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute Of Chemical Technology (KR) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011030955-A1 | INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214991-A1 | Indenone Derivative and Pharmaceutical Composition Comprising Same | INSR, HSD17B7, SOST | NPC1 151/4885RAB9A 1488/4885ADORA2A 4061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.