Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002789 | 0.87 | PARP1 (0.45) | PARP1PARP2ACHE | |
| SCHEMBL2024915 | 0.76 | PARP1 (0.43) | PARP1PARP2ACHE | |
| SCHEMBL2023586 | 0.74 | PARP1 (0.46) | PARP1PARP2ACHE | |
| SCHEMBL1002428 | 0.72 | PARP1 (0.44) | PARP1PARP2 | |
| SCHEMBL8271635 | 0.71 | PARP1 (0.39) | PARP1PARP2ACHE | |
| SCHEMBL8240044 | 0.71 | ALDH1A1 (0.47) | PARP1PARP2ACHE | |
| SCHEMBL12641815 | 0.70 | ACHE (0.46) | PARP1PARP2ACHE | |
| SCHEMBL17064545 | 0.69 | MAOA (0.53) | — | |
| SCHEMBL8240048 | 0.69 | PARP1 (0.41) | PARP1PARP2ACHE | |
| SCHEMBL2024499 | 0.69 | PARP1 (0.39) | PARP1PARP2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021309-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |