Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249756 | 0.94 | LMNA (0.33) | PLK1AGTR2AGTR1PPARGLMNA | |
| SCHEMBL12884195 | 0.91 | PTGER1 (0.37) | PPARGLMNA | |
| SCHEMBL8241502 | 0.89 | HTT (0.41) | PLK1P2RX3LMNA | |
| SCHEMBL8251911 | 0.87 | PLK1 (0.34) | PLK1AGTR2AGTR1PPARG | |
| SCHEMBL12884207 | 0.85 | PTGER1 (0.36) | PLK1LMNA | |
| SCHEMBL8242374 | 0.82 | AGTR2 (0.39) | AGTR2AGTR1PPARG | |
| SCHEMBL8252428 | 0.81 | KDR (0.32) | PLK1PPARGLMNA | |
| SCHEMBL12884184 | 0.81 | HTT (0.43) | LMNA | |
| SCHEMBL8286263 | 0.81 | CSF1R (0.44) | LMNA | |
| SCHEMBL8284704 | 0.80 | LMNA (0.40) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896450-B1 | 2-SUBSTITUTED BENZIMIDAZOLES | JANSSEN R & D IRELAND (IE) | 2012-08-15 | — | — | EP | disclosed |
| US-7884215-B2 | 2-substituted benzimidazoles | JANSSEN SCIENCES IRELAND UC (IE) | 2011-02-08 | — | — | US | disclosed |
| US-20100092426-A1 | 2-SUBSTITUTED BENZIMIDAZOLES | JANSSEN SCIENCES IRELAND UC (IE) | 2010-04-15 | — | — | US | disclosed |
| WO-2006136563-A1 | 2-SUBSTITUTED BENZIMIDAZOLES | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092426-A1 | 2-SUBSTITUTED BENZIMIDAZOLES | HTR4, HRH4, HTR3C | PLK1 2782/4885AGTR2 82/4885AGTR1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.