Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14567097 | 0.95 | MAPT (0.54) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL8988877 | 0.94 | MAPT (0.52) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL9624365 | 0.86 | MAPT (0.43) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL13725780 | 0.85 | GSK3B (0.46) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL19831100 | 0.85 | GSK3B (0.46) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL107988 | 0.84 | MAPT (0.61) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL29596363 | 0.84 | MAPT (0.61) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL107987 | 0.84 | MAPT (0.61) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL14366705 | 0.82 | MAPT (0.61) | MAPTRAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL12196115 | 0.81 | KMT2A (0.57) | MAPTRAB9AKMT2ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526942-B1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2017-08-09 | — | — | EP | disclosed |
| US-9604907-B2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2581440-B1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | UNIV NORTH CAROLINA (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2581440-A2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | The University of North Carolina at Chapel Hill (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2526942-A2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | The University of North Carolina at Chapel Hill (US) | 2012-11-28 | — | — | EP | disclosed |
| US-20070060526-A1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
| US-20070060526-A1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
| WO-2006133353-A2 | METHODS OF FACILITATING NEURAL CELL SURVIVAL USING NON-PEPTIDE AND PEPTIDE BDNF NEUROTROPHIN MIMETICS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060526-A1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | BDNF, NTRK2, NGF | MAPT 476/4885RAB9A 1732/4885KMT2A 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.